Creates the Drug Education and Youth Overdose Prevention Act. Provides that the State Board of Education shall collaborate with the Substance Use Prevention and Recovery Division of the Department of Human Services, the Department of Child and Family Services, the Department of Public Health, and the Illinois Opioid Crisis Response Advisory Council to develop improved K-12 health education standards. Provides that the improved K-12 health education standards shall be comprehensive, reality-based, safety-focused, and evidence-based standards that reduce substance use risk factors and promote protective factors. Provides that the State Board of Education shall update state-mandated K-12 health education standards. Sets forth other requirements for the updated standards. Senate Floor Amendment No. 1 Deletes reference to: New Act Adds reference to: 105 ILCS 5/22-81 Replaces everything after the enacting clause. Amends the School Code. Provides that by July 1, 2024, the State Board of Education and the Department of Human Services shall work in consultation with relevant stakeholders, including the Illinois Opioid Crisis Response Advisory Council, to develop and update substance use prevention and recovery resource materials for public elementary and secondary schools (instead of requiring the State Board and Department to develop and establish a heroin and opioid drug prevention program that offers educational materials and instruction on heroin and opioid abuse to all school districts in the State for use at their respective public elementary and secondary schools). Provides that a Substance Use Prevention and Recovery Instruction Resource Guide shall be made available on the State Board of Education's Internet website and shall be sent via electronic mail to all regional offices of education and school districts in this State. Sets forth provisions concerning the Resource Guide. Provides that, subject to appropriation, the Department shall reimburse a grantee for any costs associated with facilitating a heroin and opioid overdose prevention instructional program for school districts seeking to provide instruction under this type of program (instead of reimburse a school district that decides to participate in the program for any costs it incurs in connection with its participation in the program). Makes other changes. Effective immediately.