The DeOndra Dixon INCLUDE Project Act of 2026 amends the Public Health Service Act to establish the 'INCLUDE Project' for Down syndrome research. It requires the Director of NIH to conduct research, training, and investigation into the effects of trisomy 21, lifespan studies, clinical trials inclusion, biological mechanisms, diagnosis, treatment, and improving the quality of life for individuals with Down syndrome. The Director must coordinate related NIH institute activities, prioritize non-duplicative research, and consult with stakeholders. Biennial reports on research activities must be submitted to Congress, detailing the conducted or supported research and any resulting real-world evidence for clinical research and medical care for patients with Down syndrome.