The bill establishes the Ohio River Basin Restoration Program to improve water quality, increase community resilience, protect wildlife habitat, control invasive species, and promote public access and recreation in Ohio River States.

It creates an Ohio River National Program Office within the Environmental Protection Agency, tasked with coordinating and implementing the program and engaging with Tribal Governments.

The Program will prioritize natural infrastructure and non-structural solutions, and funds may be used for planning, design, and implementation of projects and activities by federal and non-federal entities.

Projects and activities will be selected based on equitable distribution, environmental outcomes, economic benefits, feasibility, and compatibility with navigation and disaster risk reduction infrastructure.

The bill authorizes $350,000,000 annually for fiscal years 2026 through 2030 and allows the Administrator to transfer funds to relevant federal agencies to carry out program activities.